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(A) Mitochondrial DNA copy number and (B) ATP content in renal cortex of normoglycemic control mice treated with scramble (Scr) shRNA (n = 6 each group), and streptozotocin (STZ)-induced diabetic mice (DM; n = 6 each group) treated with PRR shRNA (DM + PRR + shRNA; n = 6 each group), after eight weeks of STZ-induction of diabetes. Data are mean ± SEM. *P < 0.05 vs. Veh + Scr shRNA.
