Table 2.
Hazard ratio and 95% confidence interval for cognitive decline according to HbA1c groups at each cut-off point of HbA1c level among 1,304 older Japanese adults
| Cut-off point of HbA1c 5.6% | <5.6% group | ≥5.6% group | ||||||
| n (%) | 514 | ( | 39.4 | ) | 790 | ( | 60.6 | ) |
| Subjects with cognitive decline, n (%) | 169 | ( | 32.9 | ) | 262 | ( | 33.2 | ) |
| Multivariate-adjusted HR (95% CI)a | 1.00 | ( | reference | ) | 1.29 | ( | 1.06–1.58 | ) |
| Cut-off point of HbA1c 6.0% | <6.0% group | ≥6.0% group | ||||||
| n (%) | 979 | ( | 75.1 | ) | 325 | ( | 24.9 | ) |
| Subjects with cognitive decline, n (%) | 314 | ( | 32.1 | ) | 117 | ( | 36.0 | ) |
| Multivariate-adjusted HR (95% CI)a | 1.00 | ( | reference | ) | 1.14 | ( | 0.91–1.41 | ) |
| Cut-off point of HbA1c 6.5% | <6.5% group | ≥6.5% group | ||||||
| n (%) | 1,171 | ( | 89.8 | ) | 133 | ( | 10.2 | ) |
| Subjects with cognitive decline, n (%) | 379 | ( | 32.4 | ) | 52 | ( | 39.1 | ) |
| Multivariate-adjusted HR (95% CI)a | 1.00 | ( | reference | ) | 1.26 | ( | 0.93–1.68 | ) |
Abbreviations: HbA1c; glycosylated hemoglobin A1c (National Glycohemoglobin Standardization Program value), HR; hazard ratio, CI; confidence interval, n; number.
a Adjusted for age, sex, body mass index, smoking, total physical activity, education, medical history of hypertension and dyslipidemia (considered separately), total energy intake, alcohol intake, intake of green and yellow vegetables, fish intake, green tea intake, and MMSE scores at baseline.