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. 2019 Nov 28;10:1436. doi: 10.3389/fphys.2019.01436

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Copyright © 2019 Tharp, Haywood, Sbaizero, Taylor and Mestroni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure and domains of titin N2B and N2BA isoforms. The two cardiac isoforms and their protein kinase phosphorylation N2B and N2BA are illustrated here with their specific protein regions. Both isoforms contain the N2B unique sequence (N2Bus), and the PEVK region (titin region rich in proline, glutamate, valine, and lysine). The N2BA isoform also contains the N2A unique sequence (N2Aus). The various protein kinase binding partners are indicated in the balloons with arrows pointing to their general binding regions.