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. 2019 Nov 28;7:301. doi: 10.3389/fcell.2019.00301

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Copyright © 2019 Plummer and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The autophagy-related PI3K complex I mediates MR-dependent CLS extension. Deletion of each of the genes encoding the autophagy-related PI3K complex I members (A) Vps15, (B) Vps30, and (C) Atg14 moderately reduces the CLS of methionine-restricted yeast. Conversely, otherwise wild-type cells deleted for the genes encoding (D) Vps15 and (E) Vps30 do not negatively impact CLS. (F) Otherwise wild-type cells lacking Atg14 and (G) methionine-restricted cells lacking Vps34 are extremely short-lived. Neither (H) Vps38 nor (I) Iml1 are required for maximal extension of lifespan by G-MR. For all panels, bars denote standard error of the mean (SEM).