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. 2019 Nov 28;7:301. doi: 10.3389/fcell.2019.00301

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Copyright © 2019 Plummer and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alterations in carbon metabolism can extend CLS and are engendered by MR. (A) Wild-type yeast aged in medium containing glycerol in place of glucose (GLY) are long-lived, whereas methionine-restricted yeast receive no additional benefit from growth on glycerol when these interventions are combined (met15Δ + GLY). Determination of the varying concentrations of (B) ethanol, (C) acetate, and (D) succinate in chronologically-aged wild-type (Control) and methionine-restricted (met15Δ) yeast (Days 2–5). For panels B–D, all MR-dependent changes are highly statistically significant (p < 0.01). Bars denote SEM.