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. 2019 Dec 4;10:5518. doi: 10.1038/s41467-019-13520-8

Fig. 7. Hypothetical model for the role of M segment splicing for IAV host range.

Fig. 7

A cis-regulatory secondary structure element (indicated hairpins) in avian but not human IAV M pre-mRNA facilitates splicing. This leads to the underproduction of M1 mRNA and protein in human cells infected with avian-adapted IAVs. The poor availability of the M1 protein may contribute to an impaired nuclear export of viral ribonucleoproteins (vRNPs).