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. 2019 Dec 4;10(12):917. doi: 10.1038/s41419-019-2156-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a MOLM-13 cells were transiently transfected with siRNA against NOXA, BIM or non-targeting control siRNA (siCtrl), followed by treatment with ABT-199 for 24 h and analysis of apoptosis by staining with Annexin-V/FITC and flow cytometry. b MOLM-13 or MONO-MAC-6 cells were transiently transfected with siRNA against NOXA, BIM or non-targeting control siRNA (siCtrl), followed by treatment with S63845 for 4 h (MOLM-13) or 2 h (MONO-MAC-6) and analysis of apoptosis by staining with Annexin-V/FITC and flow cytometry. Mean and SD of at least three independent experiments performed in triplicate are shown. *P < 0.05; **P < 0.01; ***P < 0.001. c Expression levels of NOXA and BIM were assessed by Western blotting for transfected MOLM-13 and MONO-MAC-6 cells with β-Actin serving as loading control.