Skip to main content
. 2019 Dec 4;9:18300. doi: 10.1038/s41598-019-54613-0

Figure 4.

Figure 4

The PDI inhibitor bacitracin inhibits transmission in Plasmodium berghei and Plasmodium falciparum. (A–C) Triplicate P. berghei standard membrane feeding assays with Bacitracin compared to control at concentrations of 0.3, 1 and 3 mM. Individual data points represent the number of oocysts found in individual mosquitoes 12-days post feed. Horizontal bars indicate mean intensity of infection, whilst error bars indicate S.E.M within individual samples. Asterisks indicate P value < 0.05 Mann-Whitney U test, ns indicate P value not significant. (D–F) Triplicate P. falciparum standard membrane feeding assays with Bacitracin compared to control at a concentration of 3 mM. Individual data points represent the number of oocysts found in individual mosquitoes 8-days post feed. Horizontal bars indicate mean intensity of infection, whilst error bars indicate S.E.M within individual samples. Asterisks indicate P value < 0.05 Mann-Whitney U test.