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. 2019 Dec 4;10(12):924. doi: 10.1038/s41419-019-2158-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c MEC-1 and RIVA cells were treated with ibrutinib in a dose-and time-dependent manner as indicated and immunoblotted for PTEN, pAKT^Ser473, pFOXO3a^Ser253, AKT, and FOXO3a. GAPDH was used as a loading control. d MEC-1 parental and IB-R cells were treated with or without ibrutinib (10 µM) for the indicated time. Expression levels of pAKT^Ser473, FOXO3a and PTEN were determined by immunoblotting. GAPDH was used as a loading control.