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. 2019 Dec 4;9:18345. doi: 10.1038/s41598-019-54789-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose Response Curve – Levodopa Intravitreal Injections. (A) Axial length after four days of treatment for each of the tested conditions. (B) Percent protection against the axial elongation associated with diffuser wear (FD) relative to levodopa concentration administered. (C) Refractive values after four days of treatment for each of the tested conditions. (D) Percent protection against the myopic refractive shift associated with FD relative to levodopa concentration administered. Data represent mean ± standard error of the mean. FD: Form deprivation. Untreated controls: age-matched untreated controls. Statistics denote difference to FD Only; *p < 0.05, **p < 0.02, ***p < 0.001.