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. 2019 Dec 4;9:18351. doi: 10.1038/s41598-019-54830-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Modelling of PAH-associated mutations causing buried steric clashes. Structural models for the indicated mutants (A–H) were calculated using the Eris server (http://dokhlab.unc.edu/tools/eris/)²⁶. Changes in the mutant structure are coloured purple and overlaid onto the wild-type residue coloured yellow. Hydrogen bonds in the wild-type (yellow) and clashes in the mutant structure (purple) are shown by spheres and dashed lines, respectively.