Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 28;10:1437. doi: 10.3389/fphar.2019.01437

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Hong, Zhong, Xie, Zheng, Pang, Li, Yang, Xu, Mi, Cao, Zhang, Hu, Song, Wang and Zhan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Matrine suppressed messenger RNA (mRNA) transcription and protein expression of HIF-1α. (A) Western blotting shows the protein expression of HIF-1α in HCT116 and SW620 cells with 12 h treatment of 0∼8.0 mM matrine together with or without 100 μM desferrioxamine treatment. (B) HIF-1α mRNA level as quantified by quantitative real-time-PCR in HCT116 and SW620 cells with the treatment of 0∼8.0 mM matrine for 12 h. Data were expressed as mean ± SEM, n = 6. **, P < 0.01. (C) Immunohistochemistry showing the expression of HIF-1α in mouse xenograft tumors.