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. 2019 Nov 28;10:1437. doi: 10.3389/fphar.2019.01437

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Copyright © 2019 Hong, Zhong, Xie, Zheng, Pang, Li, Yang, Xu, Mi, Cao, Zhang, Hu, Song, Wang and Zhan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Matrine inhibited the transcription of glucose metabolism-related genes in colon cancer cells. (A–C) Quantitative real-time-PCR analysis of GLUT1, HK2, and LDHA in HCT116 and SW620 cells following treatment with 0∼8.0 mM matrine for 12 h. Data were expressed as mean ± SEM, n = 4∼6. *, P < 0.05. **, P < 0.01. (D) Immunohistochemistry showing the expression of GLUT1, HK2, and LDHA in mouse xenograft tumors.