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. 2019 Nov 27;10:2761. doi: 10.3389/fimmu.2019.02761

Figure 5.

Figure 5

Inhibitory activity of LDNs and NDNs on T cell proliferation and IFN-γ production. (A) Bar graphs represent the cumulative data of proliferation, expressed as fold of change, of BCG-stimulated T cells (white column) in the presence of LDNs (gray column) or NDNs (dark gray column). T cell proliferation was evaluated on the CFSE negative CD3+ T cells fraction by FACS analysis and expressed as fold of change calculated as indicated in Materials and Methods section. (B) Bar graphs represent cumulative data of IFN-γ production, by BCG-stimulated PBMCs (white column) in the presence of LDNs (gray column) and NDNs subsets (dark gray column). (C) Bar graphs represent the cumulative data of proliferation of BCG-stimulated PBMCs (white column) in the presence of LDNs (gray column) and an isotype of control and LDNs (dark gray) in the presence of a neutralizing anti-IL-10 moAb. (D) Bar graphs represent the cumulative data, of inhibition of IFN-γ production of BCG-stimulated PBMCs (white column) in the presence of LDNs (gray column), in the presence of an isotype of control and LDNs (dark gray column), and in the presence of neutralizing anti-IL-10 moAb. Data shown are cumulative data from three different patients with active TB *p < 0.05.