Figure 5.

Magnéli phases concentrate in pulmonary macrophages, resulting in significant dysfunction. (A) Representative images of BALF cytology from PBS and Ti₆O₁₁ (100 ppm) treated mice. (B) Differential cell counts in the BALF after treatment with PBS, Ti₆O₁₁, or LPS. (C) Gene expression profiling and analysis using Ingenuity Pathway Analysis software identified gene transcription patterns associated with increases in apoptosis, formation of reactive oxygen species, and wound healing/fibrosis. Data are expressed as mean ± SEM (n = 3 mice per PBS treated group, n = 7 mice per Ti₆O₁₁ treated group, and n = 4 per LPS treated group). *p < 0.05.