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. 2019 Dec 4;9:18338. doi: 10.1038/s41598-019-54722-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SPECT/CT images and pancreatic uptake. SPECT/CT scans were performed every three weeks from 6 to 15 weeks of age 30 min after intravenous injection of 3.0 MBq [¹¹¹In]Ex4. (a) Axial images are shown. Yellow arrows show pancreatic uptake and red arrows show right renal uptake. Sagittal and coronal images can be found as Supplementary Figure S1. (b) The pancreatic radioactivity (%ID/g) was significantly decreased in group db/db(c−) after 12 weeks of age, whereas no significant change was observed in group db/db(c+). After 12 weeks of age, the pancreatic radioactivity of group db/db(c+) was significantly higher than that of group db/db(c−). A plot of individual mice can be found as Supplementary Figure S2. (c) Correlation between the pancreatic radioactivity and immunohistochemically calculated BCM was observed in group db/db(c+) and db/db(c−). However, the pancreatic radioactivity of group db/m(c−) could not be plotted in the same straight line as that in group db/db(c+) and db/db(c−).