Table 2.
Pathway over-representation analysis (ORA) of the DEG.
| Time of exposure | Biological function | Name pathway | p-value |
|---|---|---|---|
| 2 h | Signal Transduction | Olfactory receptor activity | 3.03E-09 |
| Olfactory transduction | 4.73E-09 | ||
| Olfactory Signalling Pathway | 8.72E-09 | ||
| GPCR downstream Signalling | 6.47E-07 | ||
| Signalling by GPCR | 1.60E-06 | ||
| GPCRs, Class A Rhodopsin-like | 0.00518 | ||
| Signal Transduction | 0.0125 | ||
| Immune system | Staphylococcus aureus infection | 0.0113 | |
| Dectin-2 family | 0.0125 | ||
| Metabolism | Vitamin A and Carotenoid Metabolism | 0.0297 | |
| Retinol metabolism | 0.0468 | ||
| Transport | Cation-coupled Chloride cotransporters | 0.0125 | |
| 4 h | Signal Transduction | Olfactory Signalling Pathway | 1.57E-05 |
| Olfactory receptor activity | 9.53E-05 | ||
| Olfactory transduction | 9.53E-05 | ||
| GPCR downstream Signalling | 0.000714 | ||
| Signalling by GPCR | 0.000807 | ||
| GPCR Signalling-G alpha i | 0.0223 | ||
| GPCR Signalling-pertussis toxin | 0.0223 | ||
| VEGF binds to VEGFR leading to receptor dimerization | 0.0223 | ||
| VEGF ligand-receptor interactions | 0.0223 | ||
| GPCR Signalling-cholera toxin | 0.0234 | ||
| GPCR Signalling-G alpha s Epac and ERK | 0.0234 | ||
| GPCR Signalling-G alpha q | 0.0234 | ||
| VEGF and VEGFR Signalling network | 0.0234 | ||
| Signal Transduction | 0.0234 | ||
| GPCR Signalling-G alpha s PKA and ERK | 0.0234 | ||
| Metabolism | Serotonin and melatonin biosynthesis | 0.0127 | |
| Bile acid and bile salt metabolism | 0.029 | ||
| Peptide hormone metabolism | 0.029 | ||
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 0.029 | ||
| Biogenic Amine Synthesis | 0.037 | ||
| Metabolism of Angiotensinogen to Angiotensins | 0.0389 | ||
| Primary bile acid biosynthesis | 0.0407 | ||
| Amine-derived hormones | 0.044 | ||
| Transport | Ligand-gated ion channel transport | 0.00701 | |
| Transport of organic anions | 0.0234 | ||
| Transmembrane transport of small molecules | 0.029 | ||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | 0.0389 | ||
| Neuronal system | Serotonin and anxiety | 0.029 | |
| Serotonergic synapse | 0.0407 | ||
| Neuroactive ligand-receptor interaction | 0.0446 | ||
| 24 h | Signal Transduction | Gastrin-CREB Signal Transduction pathway via PKC and MAPK | 0.108 |
| Peptide ligand-binding receptors | 0.108 | ||
| Class A/1 (Rhodopsin-like receptors) | 0.108 | ||
| G alpha (i) Signal Transduction events | 0.128 | ||
| Immune system | Negative regulation of MAPK pathway | 0.131 | |
| Metabolism | Glucocorticoid Receptor Pathway | 0.00221 | |
| Glycine, serine, alanine and threonine metabolism | 0.0207 | ||
| Creatine metabolism | 0.108 | ||
| Prostaglandin Synthesis and Regulation | 0.108 | ||
| Metabolism of polyamines | 0.128 | ||
| Transport | Bile salt and organic anion SLC transporters | 0.128 | |
| Neuronal system | TarBasePathway | 0.128 | |
| HCN channels | 0.03 | ||
| Cancer | Photodynamic therapy-induced HIF-1 survival Signalling | 0.128 | |
| Gene expression (Transcription) | TP53 Regulates Transcription of Cell Cycle Genes | 0.128 | |
| Developmental biology | Endoderm Differentiation | 0.128 | |
| Developmental Biology | 0.108 | ||
| Haemostasis | Hemostasis | 0.0382 |
Pathways related to the DEG after ORA with ConsensusPathDB. The pathways were grouped per time points and per biological function.