Table 4.
Pathways associated with the DEG after NPs, MPs and E171 exposure.
| Time of exposure | Biological function | Name pathway | p-value |
|---|---|---|---|
| E171 | Signal Transduction | GPCR downstream signalling | 1.09E-08 |
| Signalling by GPCR | 3.75E-07 | ||
| Olfactory Signalling Pathway | 2.05E-06 | ||
| Olfactory transduction - Homo sapiens (human) | 3.36E-05 | ||
| Olfactory receptor activity | 6.69E-05 | ||
| GPCR ligand binding | 0.000236 | ||
| Signal Transduction | 0.000461 | ||
| G alpha (q) signalling events | 0.00222 | ||
| Bone Morphogenic Protein (BMP) Signalling and Regulation | 0.00845 | ||
| Transport of small molecules | Zinc efflux and compartmentalization by the SLC30 family | 0.00406 | |
| Neuronal system | Dopaminergic Neurogenesis | 0.0004 | |
| Developmental Biology | Interaction between L1 and Ankyrins | 0.0041 | |
| Haemostasis | Endothelins | 0.00989 | |
| Metabolism of proteins | Insulin processing | 0.00406 | |
| MPs | Signal Transduction | Olfactory Signalling Pathway | 0.0579 |
| Olfactory transduction - Homo sapiens (human) | 0.0579 | ||
| Developmental Biology | CDO in myogenesis | 0.0654 | |
| Myogenesis | 0.0654 | ||
| Netrin-1 signalling | 0.0775 | ||
| NPs | Metabolism | Glycine, serine, alanine and threonine metabolism | 0.000543 |
| Creatine metabolism | 0.000789 | ||
| Urea cycle and metabolism of amino groups | 0.00514 | ||
| Glucocorticoid Receptor Pathway | 0.00541 | ||
| Prostaglandin Synthesis and Regulation | 0.00861 | ||
| Neuronal system | HCN channels | 8.60E-05 | |
| TarBasePathway | 0.00126 | ||
| Potassium Channels | 0.00689 | ||
| Transport of small molecules | Amino acid transport across the plasma membrane | 0.00926 |
ORA analysis performed with CPDB on all the DEG after NPs, MPs and E171 exposure in vitro for 24 h.