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. 2019 Oct 3;13(5):832–846. doi: 10.1016/j.stemcr.2019.09.002

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Iron Triggers Cell Death via Ferroptosis in iPSC-Derived NPCs and Neurons

(A) MTT assay of NPCs treated with/without 80 μM of erastin and 20 μM of ferrostatin-1 for 18 h.

(B) NPCs re-plated for five passages in the presence of 2.6 μM ferrostatin-1.

(C) Neurons treated with 1 μM ferrostatin-1 during differentiation.

(D) Scheme representing the percentage of senescent and ferroptotic cells in neurons.

All results are presented as a percentage of cell viability compared with that in the isogenic controls and as the mean ± SD of three independent experiments. The data were analyzed by unpaired, two-tailed t test, ^∗∗p < 0.01, ^∗∗∗p < 0.001.