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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Microbiol. 2019 Jun 6;52:47–54. doi: 10.1016/j.mib.2019.05.001

Figure 1. Mutational patterns in the C. albicans genome.

Figure 1.

(a) Mutation accumulation varies across C. albicans chromosomes, with telomeres, repetitive regions, and genes containing repeats enriched for mutations. (b) Loss of heterozygosity (LOH) and de novo SNPs are major drivers of genetic variation. Large LOH tracts are rare and arise at the ends of chromosomes, whereas short-tract LOH events are frequent and widespread across the genome. New heterozygous SNPs arise both within and adjacent to LOH tracts.CEN, centromere; HET, heterozygous; HOM, homozygous; MRS, Major Repeat Sequence.