Skip to main content
. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Chem Biol. 2019 Jun 6;53:1–8. doi: 10.1016/j.cbpa.2019.04.026

Figure 2.

Figure 2

Knowledge of carbohydrate biosynthetic pathways in bacteria provides important information on precursors for metabolic oligosaccharide engineering (MOE).

(a) Pseudaminic and legionaminic acid biosynthesis via three-carbon extension (PEP – shown in red) of hexose precursors via the Pse (Helicobacter pylori) and Leg (Campylobacter jejuni) pathways. (b) Azide-labeled MOE precursors 1, 2, and 3 for Pse, Leg and Kdo pathways (green box). (c) Octulosonic acid biosynthesis (E. coli) via a three-carbon extension (PEP – shown in red) of a pentose precursor. (d) Cellular uptake and fate of 1 and 3 in bacterial MOE studies.