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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Chem Biol. 2019 Jun 6;53:1–8. doi: 10.1016/j.cbpa.2019.04.026

Figure 3.

Figure 3

Cellular signaling with a bacterial monosaccharide.

(a) The ADP-heptose biosynthesis pathway illustrating the transketolase step, which establishes the seven-carbon skeleton. The key intermediate, HBP, is highlighted in a blue box. (b) Cellular delivery of bacterial HBP by various pathogens and signaling cascade initiated by activation of ALPK1 ultimately leading to transcriptional regulation via NF-κB stimulating an inflammatory response.