TABLE 2.

Overall case-control analyses for psychiatric conditions before the index date.

	Bilateral oophorectomy (N=1,653)		Control women (N=1,653)		Unadjusted models^b		Adjusted models^c
Condition^a	N	%	N	%	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P
Mood disorders	529	32.0	346	20.9	1.79 (1.53-2.11)	<0.001	1.77 (1.51-2.09)	<0.001
Bipolar disorders	31	1.9	18	1.1	1.76 (0.97-3.20)	0.06	1.71 (0.94-3.12)	0.08
Anxiety disorders	236	14.3	189	11.4	1.30 (1.06-1.61)	0.01	1.29 (1.04-1.59)	0.02
Schizophrenia	7	0.4	13	0.8	0.54 (0.21-1.35)	0.19	0.57 (0.23-1.46)	0.24
Somatoform disorders	34	2.1	9	0.5	3.78 (1.81-7.88)	<0.001	3.65 (1.75-7.64)	<0.001
Personality disorders	37	2.2	20	1.2	1.94 (1.10-3.43)	0.02	1.90 (1.07-3.38)	0.03
Dissociative disorders	12	0.7	8	0.5	1.50 (0.61-3.67)	0.37	1.42 (0.57-3.53)	0.45
Adjustment disorders	123	7.4	112	6.8	1.11 (0.85-1.45)	0.45	1.13 (0.86-1.48)	0.38
Number of conditions^d
0	980	59.3	1,158	70.1	1.00 (reference)^e		1.00 (reference)^e
1	427	25.8	323	19.5	1.55 (1.31-1.83)	<0.001	1.55 (1.31-1.83)	<0.001
2	185	11.2	138	8.3	1.62 (1.27-2.07)	<0.001	1.61 (1.26-2.06)	<0.001
≥3	61	3.7	34	2.1	2.22 (1.43-3.45)	<0.001	2.19 (1.40-3.41)	<0.001

Psychiatric conditions before the index date were determined from abstraction of the medical records.

Odds ratios calculated using conditional logistic regression models (matched pairs).

Odds ratios calculated using conditional logistic regression models (matched pairs), adjusted for race (white vs nonwhite), years of education (≤12, 13-16, >16), and quartiles of household income (<$42,000, $42,000-56,999, $57,000-71,999, ≥$72,000). Women missing years of education (3 cases, 35 controls) were assigned to the ≤12 years group and women missing household income (6 cases, 2 controls) were assigned to the second quartile.

Total number of psychiatric conditions before the index date for each woman.

Cochrane-Armitage test for linear trend in the odds ratios, P<0.001 for the unadjusted models and P<0.001 for the adjusted models.