TABLE 3.

Case-control analyses for psychiatric conditions before the index date, stratified by age at index date.

	Bilateral oophorectomy (N=1,031 age ≤45, N=622 age 46-49)		Control women (N=1,031 age ≤45, N=622 age 46-49)		Unadjusted models^b		Adjusted models^c
Condition^a	N	%	N	%	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P	Interaction P
Mood disorders
Age ≤45 years	363	35.2	205	19.9	2.22 (1.81-2.74)	<0.001	2.16 (1.75-2.66)	<0.001	0.003
Age 46-49 years	166	26.7	141	22.7	1.25 (0.96-1.62)	0.10	1.29 (0.99-1.68)	0.06
Bipolar disorders
Age ≤45 years	24	2.3	13	1.3	1.92 (0.95-3.85)	0.07	1.71 (0.84-3.50)	0.14	0.72
Age 46-49 years	7	1.1	5	0.8	1.40 (0.44-4.41)	0.57	1.34 (0.42-4.26)	0.63
Anxiety disorders
Age ≤45 years	150	14.5	101	9.8	1.57 (1.20-2.06)	0.001	1.56 (1.19-2.06)	0.002	0.04
Age 46-49 years	86	13.8	88	14.1	0.97 (0.69-1.36)	0.86	0.97 (0.69-1.37)	0.88
Schizophrenia
Age ≤45 years	3	0.3	9	0.9	0.33 (0.09-1.23)	0.10	0.31 (0.08-1.16)	0.08	0.19
Age 46-49 years	4	0.6	4	0.6	1.00 (0.25-4.00)	1.00	1.13 (0.28-4.55)	0.87
Somatoform disorders
Age ≤45 years	23	2.2	4	0.4	5.75 (1.99-16.63)	0.001	5.09 (1.75-14.86)	0.003	0.30
Age 46-49 years	11	1.8	5	0.8	2.20 (0.76-6.33)	0.14	2.31 (0.80-6.68)	0.12
Personality disorders
Age ≤45 years	26	2.5	15	1.5	1.85 (0.94-3.63)	0.08	1.74 (0.88-3.45)	0.11	0.63
Age 46-49 years	11	1.8	5	0.8	2.20 (0.76-6.33)	0.14	2.36 (0.81-6.90)	0.12
Dissociative disorders
Age ≤45 years	8	0.8	7	0.7	1.14 (0.41-3.15)	0.80	0.98 (0.35-2.75)	0.96	0.22
Age 46-49 years	4	0.6	1	0.2	4.00 (0.45-35.79)	0.22	4.49 (0.48-41.75)	0.19
Adjustment disorders
Age ≤45 years	60	5.8	75	7.3	0.79 (0.55-1.12)	0.18	0.80 (0.56-1.15)	0.23	0.004
Age 46-49 years	63	10.1	37	5.9	1.84 (1.19-2.85)	0.006	1.85 (1.19-2.88)	0.006

Psychiatric conditions before the index date were determined from abstraction of the medical records.

Odds ratios calculated using conditional logistic regression models (matched pairs).

Odds ratios calculated using conditional logistic regression models (matched pairs), adjusted for race (white vs nonwhite), years of education (≤12, 13-16, >16), and quartiles of household income (<$42,000, $42,000-56,999, $57,000-71,999, ≥$72,000). The interaction p-values were calculated using adjusted conditional logistic regression models (matched pairs) which also included a variable for the multiplicative interaction between each psychiatric condition and age (≤45 years vs 46-49 years). Women missing years of education (age ≤45 years: 2 cases, 23 controls; age 46-49 years: 1 case, 12 controls) were assigned to the ≤12 years group and women missing household income (age ≤45 years: 5 cases, 2 controls; age 46-49 years: 1 case, 0 controls) were assigned to the second quartile.