TABLE 4.

Case-control analyses for psychiatric conditions before the index date, stratified by oophorectomy indication.

	Bilateral oophorectomy (N=675 indication, N=978 no indication)		Control women (N=675 indication, N=978 no indication)		Unadjusted models^b		Adjusted models^c
Condition^a	N	%	N	%	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P	Interaction P
Mood disorders
Benign indication	209	31.0	138	20.4	1.73 (1.35-2.22)	<0.001	1.69 (1.31-2.18)	<0.001	0.58
No ovarian indication	320	32.7	208	21.3	1.84 (1.49-2.27)	<0.001	1.86 (1.50-2.30)	<0.001
Bipolar disorders
Benign indication	16	2.4	3	0.4	5.33 (1.55-18.30)	0.008	5.58 (1.55-20.08)	0.008	0.02
No ovarian indication	15	1.5	15	1.5	1.00 (0.48-2.10)	1.00	0.96 (0.46-2.02)	0.92
Anxiety disorders
Benign indication	78	11.6	73	10.8	1.08 (0.77-1.50)	0.67	1.04 (0.74-1.47)	0.82	0.12
No ovarian indication	158	16.2	116	11.9	1.47 (1.12-1.93)	0.005	1.48 (1.12-1.94)	0.005
Schizophrenia
Benign indication	3	0.4	2	0.3	1.50 (0.25-8.98)	0.66	1.70 (0.28-10.35)	0.57	0.18
No ovarian indication	4	0.4	11	1.1	0.36 (0.12-1.14)	0.08	0.39 (0.12-1.25)	0.11
Somatoform disorders
Benign indication	20	3.0	4	0.6	5.00 (1.71-14.63)	0.003	4.67 (1.57-13.88)	0.006	0.47
No ovarian indication	14	1.4	5	0.5	2.80 (1.01-7.77)	0.048	2.69 (0.96-7.54)	0.06
Personality disorders
Benign indication	13	1.9	5	0.7	3.00 (0.97-9.30)	0.06	2.80 (0.88-8.86)	0.08	0.43
No ovarian indication	24	2.5	15	1.5	1.64 (0.85-3.19)	0.14	1.63 (0.83-3.18)	0.16
Dissociative disorders
Benign indication	4	0.6	3	0.4	1.33 (0.30-5.96)	0.71	0.97 (0.20-4.64)	0.97	0.61
No ovarian indication	8	0.8	5	0.5	1.60 (0.52-4.89)	0.41	1.61 (0.52-5.01)	0.41
Adjustment disorders
Benign indication	37	5.5	53	7.9	0.67 (0.43-1.04)	0.08	0.70 (0.44-1.11)	0.13	0.007
No ovarian indication	86	8.8	59	6.0	1.51 (1.07-2.14)	0.02	1.53 (1.08-2.18)	0.02

Psychiatric conditions before the index date were determined from abstraction of the medical records.

Odds ratios calculated using conditional logistic regression models (matched pairs).

Odds ratios calculated using conditional logistic regression models (matched pairs), adjusted for race (white vs nonwhite), years of education (≤12, 13-16, >16), and quartiles of household income (<$42,000, $42,000-56,999, $57,000-71,999, ≥$72,000). The interaction p-values were calculated using adjusted conditional logistic regression models (matched pairs) which also included a variable for the multiplicative interaction between each psychiatric condition and surgical indication (benign indication vs no ovarian indication). Women missing years of education (benign indication: 3 cases, 15 controls; no ovarian indication: 0 cases, 20 controls) were assigned to the ≤12 years group and women missing household income (benign indication: 3 cases, 2 controls; no ovarian indication: 3 cases, 0 controls) were assigned to the second quartile.