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. Author manuscript; available in PMC: 2020 Dec 3.
Published in final edited form as: Cell Metab. 2019 Sep 26;30(6):1131–1140.e7. doi: 10.1016/j.cmet.2019.08.023

Figure 4. Miro1 Reducer Rescues PD-Relevant Phenotypes in Flies.

Figure 4.

For all panels, when Miro1 Reducer was not added, the same volume of the solvent, DMSO, was supplied in fly food. Drug administration (2.5 μM) was started from day 2. (A-C) Survival curves of LRRK2G2019S (A), PINK1B9 (imprecise excision, null) and PINK1RV (the precise excision control for PINK1B9) (B), and SNCAA53T flies (C). n=58-150. (D) Dopaminergic (DA) neurons in the PPM1/2 clusters of 22-day old flies were immunostained with anti-TH. (D-F) Quantification of the DA neuron number in the PPL1 or PPM1/2 cluster (total number divided by 2 for each brain). (D) LRRK2 G2019S. n=6-8 brains. (E) PINK1B9 (“−”) and PINK1RV (“+”). n=9-16. (F) SNCAA53T. n=9-11. (G-I) Climbing ability (Average PI±S.E.M) of adult flies. n=24-47 flies. See also Figure S3–S4.