Table 4. Results of the gene-set analysis for the direct comparison IBT glycerol vs. IBT glucose. Gene-sets have been manually curated to reduce redundancy and only gene sets with p-value < 0.05 are shown. The amount of significant genes (p-value < 0.05) in a gene-set are provided together with the total amount of genes in the gene-set. Up: gene sets containing mainly upregulated genes. Down: gene sets containing mainly downregulated genes.

	Gene-set	Gene-set p-value	sig. genes	GO term
	amino acid transmembrane transport	1.00E-04	5 / 30	GO:0003333
	carbohydrate metabolic process	1.00E-04	8 / 69	GO:0005975
	oxidation-reduction process	1.00E-04	27 / 411	GO:0055114
	proteolysis	1.00E-04	10 / 176	GO:0006508
	pyridoxal phosphate binding	1.00E-04	10 / 51	GO:0030170
up	sequence-specific DNA binding RNA polymerase II transcription factor activity	1.00E-04	9 / 63	GO:0000981
	transmembrane transport	1.00E-04	27 / 308	GO:0055085
	transport	1.00E-04	20 / 332	GO:0006810
	glycerolipid metabolic process	1.44E-04	4 / 45	GO:0046486
	catalytic activity	1.50E-04	27 / 357	GO:0003824
	cell cycle	1.00E-04	5 / 59	GO:0007049
	cellular response to DNA damage stimulus	1.00E-04	4 / 37	GO:0006974
	DNA binding	1.00E-04	28 / 297	GO:0003677
	DNA repair	1.00E-04	6 / 92	GO:0006281
	helicase activity	1.00E-04	6 / 84	GO:0004386
down	methylation	1.00E-04	5 / 88	GO:0032259
	nucleic acid binding	1.00E-04	26 / 308	GO:0003676
	protein heterodimerization activity	1.00E-04	4 / 28	GO:0046982
	RNA binding	1.00E-04	8 / 177	GO:0003723
	RNA splicing	1.00E-04	6 / 38	GO:0008380
	damaged DNA binding	2.00E-04	4 / 14	GO:0003684