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. 2019 Nov 22;2019:4748312. doi: 10.1155/2019/4748312

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Copyright © 2019 Xiaolong Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ghrelin-induced regulation of prostate size and gene expression in rats with testosterone-induced BPH. (a) Testosterone supplementation (3 mg/kg b.w., s.c., daily) for four weeks induces prostate enlargement in rats (compare sham with BPH), which was aggravated by ghrelin (10 μg/kg body weight, i.p., 14 d) (representative images, n = 8 rats/group). (b) Prostate weight, body weight, and the ratio of prostate and body weight in sham-treated, BPH, and ghrelin-treated BPH rats. Shown are data of all rats from a series including n = 8 rats/group and descriptive p values (Friedman two-way ANOVA by ranks). (c) Numbers and functions of ghrelin-regulated genes in prostates from rats with testosterone-induced BPH, identified by microarray analysis (n = 3 rats per group, i.e., BPH rats treated with ghrelin or vehicle). Putative function of genes, which were up- or downregulated 1-fold or more by ghrelin, was checked by research in databases. Subsequently, genes were sorted to indicated categories.