Figure 4.

The genetic network for the stem cell fate vs. meiotic development decision. Top, model of the genetic network of gene products that promote the stem cell fate (green) by inhibition of three meiotic entry pathways, as well as inhibition of meiotic chromosome axis and SC protein expression (red), which together promote meiotic development. Arrows indicates positive regulation, lines with bar indicate inhibition. Bottom, regulatory class and location. DSL ligands, expressed in the niche/DTC, activate GLP-1 Notch in germ cells, leading to generation of GLP-1(ICD), which forms a transcriptional complex that results in spatially restricted expression of LST-1 and SYGL-1 that, together with ubiquitous PZ expressed FBF-1 and FBF-2, act in post-transcriptional repression of gene products that promote meiotic development.