Table 2. Genes that promote the stem cell fate—enhancer of glp-1 hypomorph.
| Genea,b | Product | Human homolog | Site of action | Reference(s) |
|---|---|---|---|---|
| Cyclin E/CDK2 | ||||
| cye-1 | Cyclin E | CCNE1 | Germ line | Fox et al. (2011) |
| cdk-2 | Cyclin-dependent kinase | CDK2 | Germ line | Fox et al. (2011) |
| RAF-ERK MAP Kinase signaling | ||||
| lin-45 | Mitogen activated protein kinase kinase kinase | BRAF | Germ line | Lee et al. (2007) |
| mek-2 | Mitogen activated protein kinase kinase | MAP2K2 | Germ line | Lee et al. (2007) |
| mpk-1 | Mitogen activated protein kinase | MAPK1 (Erk) | Germ line | Lee et al. (2007) |
| CSR-1 complex | ||||
| ego-1 | RNA-dependent RNA polymerase | — | Germ line | Qiao et al. (1995); Smardon et al. (2000) |
| csr-1 | Argonaut | — | Germ line | She et al. (2009) |
| drh-3 | DEAH/D-box helicase | DHX58 | Germ line | She et al. (2009) |
| ekl-1 | Tudor domain protein | — | Germ line | She et al. (2009) |
| TOR signaling | ||||
| rsks-1 | Ribosomal protein S6 kinase | RPS6KB2 | Germ line | Korta et al. (2012) |
| Miscellaneous | ||||
| hsp-90 | Chaperone | HSP90 | Lissemore et al. (2018) | |
| ego-2 | Protein tyrosine phosphatase, nonreceptor type 23 | PTPN23 | DTC | Qiao et al. (1995); Liu and Maine (2007) |
| atx-2 | RNA-binding protein | ATXN2L | Ciosk et al. (2004); Maine et al. (2004) | |
| iffb-1 | Eukaryotic translation initiation factor | EIF5B | Germ line | Yu et al. (2006) |
a
Enhancement of glp-1 temperature-sensitive (ts) reduction-of-function (rf) allele, at the permissive temperature (noted in the text as “glp-1(rf-ts) pt”), to a Glp-1–like phenotype in which all germline stem cells enter meiosis; glp-1 ts allele employed depends on study, either bn18, q231, or e2141.
b
Genes that function in the core Notch signaling pathway that were identified based on enhancement of glp-1 ts are listed in Table 1.