Table 2. SNPs with P-value < 2 × 10⁻⁷ in at least one of the longitudinal tests in the entire VACS sample.

Chr	Gene Region	SNP	Position	MAF	GEE (ind)	GEE (AR1)	GMMAT	L-BRAT (ind)	L-BRAT (AR1)	RGMMAT	CARATa(BL)	CLb(traj)
3	NIPA2P2	rs551879660	75,146,492	0.012	1.87 × 10−4	7.14 × 10−4	9.07 × 10−4	2.00 × 10−8	3.19 × 10−6	4.13 × 10−5	5.78 × 10−4	3.35 × 10−5
5	EFNA5	rs188222191	105,411,547	0.042	6.86 × 10−6	1.65 × 10−5	8.87 × 10−5	1.28 × 10−7	4.17 × 10−7	2.69 × 10−6	8.95 × 10−5	2.72 × 10−5
		rs1014278	105,471,506	0.057	1.02 × 10−5	1.10 × 10−5	1.24 × 10−4	1.50 × 10−7	1.43 × 10−7	4.88 × 10−6	5.94 × 10−5	3.00 × 10−5
		rs75132056	105,480,442	0.05	1.05 × 10−5	2.42 × 10−5	1.89 × 10−4	8.92 × 10−8	2.89 × 10−7	8.55 × 10−6	2.59 × 10−4	2.31 × 10−5
8	PSD3	rs114629793	18,403,754	0.012	3.12 × 10−4	4.73 × 10−4	1.44 × 10−4	8.65 × 10−8	3.60 × 10−7	2.82 × 10−6	5.12 × 10−4	3.06 × 10−6
9	OR1L4	rs76386683	125,467,023	0.012	1.48 × 10−4	9.15 × 10−5	2.86 × 10−4	1.03 × 10−6	1.93 × 10−7	5.92 × 10−6	4.80 × 10−4	3.30 × 10−6
		rs114386843	125,469,425	0.012	1.47 × 10−4	9.05 × 10−5	2.82 × 10−4	1.01 × 10−6	1.88 × 10−7	5.78 × 10−6	4.75 × 10−4	3.22 × 10−6
		rs186274502	125,471,416	0.012	1.47 × 10−4	9.05 × 10−5	2.82 × 10−4	1.01 × 10−6	1.88 × 10−7	5.78 × 10−6	4.75 × 10−4	3.22 × 10−6
		rs376616438	125,472,267	0.012	1.44 × 10−4	8.95 × 10−5	2.77 × 10−4	9.79 × 10−7	1.85 × 10−7	5.62 × 10−6	4.79 × 10−4	3.20 × 10−6
		rs187855416	125,474,459	0.012	1.44 × 10−4	8.95 × 10−5	2.77 × 10−4	9.79 × 10−7	1.85 × 10−7	5.62 × 10−6	4.79 × 10−4	3.20 × 10−6
11	AP000851.1	rs139780693	102,509,700	0.03	2.60 × 10−5	1.04 × 10−5	2.78 × 10−4	5.83 × 10−7	1.26 × 10−7	1.35 × 10−5	1.06 × 10−4	2.00 × 10−6
13	AL161616.2	rs150191017	31,962,649	0.011	4.26 × 10−5	9.72 × 10−5	7.32 × 10−5	3.77 × 10−8	3.09 × 10−7	7.87 × 10−7	3.74 × 10−4	5.48 × 10−7

The smallest P-value among all tests at the given SNPs are in bold.

^aCARAT applied to cocaine use at baseline.

^bCumulative logit model applied to the four ordered cocaine use trajectory group.