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Formation of midline glia. The sim gene is a master regulator of midline cell fate, and initially commits midline cells to an MP4 neural precursor fate. Notch signaling directs a group of midline cells to become AMG, in part by maintaining expression of sim in midline glia. Hh signaling directs formation of PMG, in part by activating expression of en. The Runt and En TFs cross-repress and lock in AMG and PMG fates.
