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. 2019 Oct 24;213(4):1111–1144. doi: 10.1534/genetics.119.300974

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Copyright © 2019 by the Genetics Society of America

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Temporal transcription factor (TTF) and subtemporal transcription factor (STTF) gene cascades. (A) Progression of TTF in the NB 7-1 lineage. The U1–5 neurons are generated from GMCs 1–5. The corresponding NBs express Hb → Kr → Pdm → Cas and Pdm. Levels of Hb are higher in NB 1 (dark blue) in comparison to NB 2 (light blue). (B) In the NB 5–6T lineage, the AP1–4 neurons are generated from Type 0-dividing NBs that are present in a Cas temporal window. AP1 and AP4 are peptidergic (Nplp1 and FMRFa, respectively) and AP2/3 are not peptidergic. AP2-4 are distinct from AP1 due to the action of the Sqz and Nab STTFs that repress col. Adapted by permission from Elsevier: Cell (Baumgardt et al. 2009) copyright (2009).