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. 2019 Nov 6;9(11):190187. doi: 10.1098/rsob.190187

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — The Notch niche in primary and secondary lymphoid organs. (a) Developing CD4⁻CD8⁻ (‘double-negative’) thymocytes receive essential Notch signals from Delta-like 4 Notch ligands expressed by thymic epithelial cells. These ligands interact with Notch1 receptors in developing T cells. The specialized thymic niche for T cell development also releases chemokines to attract early T lineage progenitors and Stem Cell Factor (SCF) to support their survival. (b) Mature T cells receive Notch signals from Delta-like 1 and 4 Notch ligands expressed by non-haematopoietic fibroblastic stromal cells in secondary lymphoid organs. These ligands interact with Notch1 and Notch2 expressed by mature T cells. This niche also provides chemokines to attract circulating T cells in the periphery and an IL-7 pro-survival signal.