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. 2019 Oct 24;11(11):1629. doi: 10.3390/cancers11111629

Figure 1.

Figure 1

Gene expression and methylation analyses of CCAAT-enhancer binding protein type alpha (C/EBP-α) and peroxisome proliferator-activated receptor gamma (PPAR-γ) in visceral adipose tissue (VAT): Quantitative RT-PCR of C/EBP-α (a) and PPAR-γ (b) expression analyses and methylation analyses at specific CpG dinucleotides for C/EBP-α (c) and PPAR-γ (d) promoters was used to compare the nonobese control (N = 53), nonobese CRC (N = 27), overweight/obese control (N = 81), and overweight/obese CRC groups (N = 58). The mRNA expression of C/EBP-α and PPAR-γ were normalized to Peptidylprolyl Isomerase A (PPIA) expression. The results are given as the mRNA relative mean expression ± SD and methylation average ± SD. Significant differences between the means of the different groups of subjects was performed according to the Wilcoxon test (p < 0.05). Abbreviations: C/EBP-α: CCAAT/enhancer-binding protein type alpha; PPAR-γ2: peroxisome proliferator-activated receptor gamma; VAT: Visceral adipose tissue.