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. 2019 Nov 18;11(11):1073. doi: 10.3390/v11111073

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model of KSHV B cell disorder development. (A) Stem cells develop into immature B cells in the bone marrow. (B) Transitional B cells expressing Immunoglobulin M-lambda light chain can be found in the bone marrow, peripheral blood or spleen. (C) Naïve/mature B cells migrate to the secondary lymphoid organs. (D) The development of MCD in the secondary lymphoid organs. (E) The development of PEL in body cavities such as the pleural space, pericardium, and peritoneum. PEL: primary effusion lymphoma; MCD: multicentric Castleman’s disease.