Table 1.

Summary of KSHV glycoprotein interactions with receptors on pertinent cell types. In the left column, several KSHV-susceptible cell types are indicated with corresponding entry receptors indicated adjacently. The top row indicates glycoproteins known to interact with the indicated receptors, which are believed to be important for entry into the cross-referenced cell type. All the listed glycoproteins are known to bind HSPG with the addition of ORF4, which is not listed [33,35]. HSPG is present on the majority of cells with the exception of B cells. * Recent studies show that these interactions may not always be necessary [36,37]. EphA2: Ephrin receptor A2.

	Virion Glycoprotein
Cell Type	gB	gHgL	K8.1A
Endothelial	α3β1 [38,39], αVβ3 [39], αVβ5 [39]	EphA2 [40,41,42]
Epithelial	α3β1 [39], αVβ3 [39,43,44], αVβ5 [39] *	EphA2 [40,41,42] EphA4 [45]
Fibroblasts	α3β1 [38,39], αVβ3 [39], αVβ5 [39]
Monocytes	DC-SIGN [46,47], α3β1 [47], αVβ3 [47], αVβ5 [47], αVβ1 [47]
Macrophages	DC-SIGN [46]
Dendritic cells	DC-SIGN [46]
B cells	DC-SIGN (activated B cells) [48]	EphA7 in cell–cell spread [49] *	K8.1A needed [34]