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. 2019 Oct 25;11(11):2581. doi: 10.3390/nu11112581

Figure 3.

Figure 3

PF04620110 decreases SBP and triglyceride levels but does not affect SNA in rats fed 10% fructose water. (A) Time course of SBP. SBP was examined after oral administration of PF04620110 for seven days. The filled circles (●) represent the control group, and open circles (○) represent the control+PF04620110 group. The inverted filled triangles (▼) represent the fructose group, and open triangles (△) represent the fructose+PF04620110 group. (B) Triglyceride levels in serum were determined after oral administration of PF04620110 for seven days. (C) The representative traces show the baseline renal SNA in each group on day 7. The time scale is one integrated value per 5 s. (D) Renal SNA was measured in each group at day 7. Renal SNA increased in fructose-fed rats. Treatment with PF04620110 did not attenuate sympathetic activation in fructose-fed rats. (E) NO concentrations were determined in the NTS of rats after oral administration of PF04620110 for seven days. NO concentrations decreased in fructose-fed rats. PF04620110 treatment did not improve NO concentrations in fructose-fed rats. The data are presented as the mean ± SEM (n = 4–8). * p < 0.05 versus the control group. # p < 0.05 versus the fructose group.