. 2019 Oct 28;11(11):2589. doi: 10.3390/nu11112589

Table 3.

Correlations between milk leptin, adiponectin and miRNAs at the second month of lactation and their relationship with infant BMI at 2 years of age.

			Adiponectin	miR-30a	miR-27a	miR-27b	miR-148a	miR-let7a	miR-let7b	miR-103	miR-17	miR-181a	miR-222	miR-let7c	miR-146b	miR-200b
Leptin	Whole	r	0.214	−0.195	−0.092	−0.165	−0.064	−0.146	−0.151	−0.325 ^*	−0.198	−0.172	−0.162	−0.110	−0.263	−0.184
	Whole	p	0.117	0.161	0.508	0.233	0.647	0.322	0.275	0.016	0.160	0.214	0.246	0.428	0.071	0.206
	Normal-weight	r	0.089	−0.454 ^**	−0.380 ^*	−0.410 ^*	−0.150	−0.328	−0.276	−0.574 ^**	−0.419 ^*	−0.470 ^**	−0.471 ^**	−0.261	−0.473 ^**	−0.297
	Normal-weight	p	0.605	0.006	0.022	0.013	0.381	0.072	0.103	0.000	0.014	0.004	0.004	0.125	0.007	0.098
	Overweight/Obese	r	0.136	0.159	0.352	0.180	0.112	0.170	0.248	0.114	0.301	0.267	0.386	0.214	0.139	0.055
	Overweight/Obese	p	0.580	0.529	0.152	0.476	0.670	0.513	0.321	0.654	0.224	0.283	0.113	0.394	0.596	0.833
Adiponectin	Whole	r	1,000	−0.345 ^*	−0.123	−0.198	−0.353 ^**	−0.374 ^**	−0.403 ^**	−0.365 ^**	−0.425 ^**	−0.275 ^*	−0.310 ^*	−0.329^*	−0.293 ^*	−0.248
	Whole	p		0.011	0.374	0.152	0.010	0.009	0.003	0.007	0.002	0.044	0.024	0.015	0.043	0.086
	Normal-weight	r	1,000	−0.325	−0.071	−0.134	−0.388 ^*	−0.467 ^**	−0.384 ^*	−0.393^*	−0.418 ^*	−0.204	−0.299	−0.319	−0.240	−0.207
	Normal-weight	p		0.057	0.682	0.435	0.019	0.008	0.021	0.018	0.014	0.232	0.081	0.058	0.193	0.255
	Overweight/Obese	r	1,000	−0.209	−0.184	−0.291	−0.222	−0.006	−0.151	−0.180	−0.250	−0.164	−0.163	−0.313	−0.085	−0.098
	Overweight/Obese	p		0.406	0.465	0.241	0.392	0.981	0.550	0.476	0.317	0.515	0.518	0.206	0.747	0.708
BMI24	Whole	r	0.125	−0.246	−0.167	−0.218	−0.252	−0.326 ^*	−0.278	−0.425 ^**	−0.298 ^*	−0.238	−0.298 ^*	−0.331 ^*	−0.287	−0.347 ^*
	Whole	p	0.380	0.085	0.245	0.129	0.081	0.031	0.051	0.002	0.040	0.096	0.037	0.019	0.059	0.020
	Normal-weight	r	0.199	−0.302	−0.196	−0.276	−0.207	−0.296	−0.313	−0.521 ^**	−0.427 ^*	−0.347 ^*	−0.385 ^*	−0.360 ^*	−0.422 ^*	−0.327
	Normal-weight	p	0.260	0.082	0.267	0.114	0.239	0.120	0.071	0.002	0.015	0.044	0.027	0.036	0.023	0.078
	Overweight/Obese	r	−0.124	−0.224	−0.179	−0.071	−0.377	−0.379	−0.285	−0.265	−0.171	−0.106	−0.138	−0.276	−0.218	−0.318
	Overweight/Obese	p	0.636	0.405	0.506	0.795	0.166	0.164	0.284	0.322	0.528	0.696	0.610	0.300	0.435	0.248

Whole population was segregated at sampling time into normal-weight mothers (BMI < 25) and overweight/obese (BMI ≥ 25). Associations between milk leptin, adiponectin, and miRNAs in breast milk at the second month of lactation and with infant BMI at 24 months of age (BMI24) were tested by Spearman’s correlation test. Spearman's rank correlation coefficient (r) and significance (p) are shown. ** = p < 0.01 (bilateral); * = p < 0.05 (bilateral). The miRNAs studied are described as miR- followed by their specific code.