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. 2019 Nov 20;5(2):e12849. doi: 10.2196/12849

Table 3.

Crude hazard ratios based on competing risk regression model to assess characteristics associated with neuroendocrine tumors–related mortality (N=96).

Characteristic and categorya Deaths (N) Crude hazard ratiob (95% CI) P value
Age at diagnosis (years)

≤65 8 Reference
>65 9 1.57 (0.62-4.01) .34
Sex

Male 7 1.08 (0.41-2.86) .87
Female 10 Reference
Neuroendocrine tumor site

Lung 10 1.41 (0.44-4.55) .01
Gastroenteropancreatic 3 0.14 (0.03-0.63) .56
Other 4 Reference
Grade at diagnosis

1 2 Reference
2/3 5 6.83 (1.36-34.21) .02
Remoteness category

City 11 1.89 (0.70-5.13) .21
Regional/remote 6 Reference
Resection surgery

No 13 35.31 (7.69-162.2)c .001
Yes 4 Reference
Stage at diagnosis

Localized/regional 6 Reference
Distant 11 3.93 (1.44-10.74) .01
Tumor size category

<20 mm 3 Reference
≥20 mm 7 2.19 (0.57-8.49) .26

aInformation on grade was missing at diagnosis for 34 patients, on resection surgery for 1 patient, on stage at diagnosis for 1 patient, and on tumor size for 27 patients.

bHazard ratio was based on the competing risk regression model (Fine and Gray hazard model), and “death due to other causes” was considered a competing risk.

cHazard ratio adjusted for time interaction.