Table 3.
Crude hazard ratios based on competing risk regression model to assess characteristics associated with neuroendocrine tumors–related mortality (N=96).
| Characteristic and categorya | Deaths (N) | Crude hazard ratiob (95% CI) | P value | |
| Age at diagnosis (years) | ||||
|
|
≤65 | 8 | Reference |
|
| >65 | 9 | 1.57 (0.62-4.01) | .34 | |
| Sex | ||||
|
|
Male | 7 | 1.08 (0.41-2.86) | .87 |
| Female | 10 | Reference |
|
|
| Neuroendocrine tumor site |
|
|||
|
|
Lung | 10 | 1.41 (0.44-4.55) | .01 |
| Gastroenteropancreatic | 3 | 0.14 (0.03-0.63) | .56 | |
| Other | 4 | Reference |
|
|
| Grade at diagnosis | ||||
|
|
1 | 2 | Reference |
|
| 2/3 | 5 | 6.83 (1.36-34.21) | .02 | |
| Remoteness category | ||||
|
|
City | 11 | 1.89 (0.70-5.13) | .21 |
| Regional/remote | 6 | Reference |
|
|
| Resection surgery | ||||
|
|
No | 13 | 35.31 (7.69-162.2)c | .001 |
| Yes | 4 | Reference |
|
|
| Stage at diagnosis | ||||
|
|
Localized/regional | 6 | Reference |
|
| Distant | 11 | 3.93 (1.44-10.74) | .01 | |
| Tumor size category | ||||
|
|
<20 mm | 3 | Reference |
|
| ≥20 mm | 7 | 2.19 (0.57-8.49) | .26 | |
aInformation on grade was missing at diagnosis for 34 patients, on resection surgery for 1 patient, on stage at diagnosis for 1 patient, and on tumor size for 27 patients.
bHazard ratio was based on the competing risk regression model (Fine and Gray hazard model), and “death due to other causes” was considered a competing risk.
cHazard ratio adjusted for time interaction.