Potato RS attenuates GI hypertrophy and systemic inflammation. The HF diet increased villi length compared to chow control which were reduced in RS supplemented rats (A). The HF feeding led to a significant increase in pro-inflammatory LPS circulating levels, which was normalized by RS supplementation (B). Similarly, HF-diet driven increases in circulating TNFα (C) and IL-6 (F) were reduced in HFRS rats. Both HF and HFRS animals display a significant decrease in circulating IL-10 (D). There were no differences among groups in serum IL-1β (E). LPS = lipopolysaccharides, TNFα = tumor necrosis factor-a, IL-10 = interleukin 10, IL-6 = Interleukin 6, IL-1β = Interleukin 1 Beta, HF = high fat, HFRS = high-fat resistant starch, all significance determined at p < 0.05. n = 8 per group. Data are presented as the mean ± SEM; a, b, c different letters indicate statically significant differences among groups.