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. 2019 Nov 2;11(11):1018. doi: 10.3390/v11111018

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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NoV genotype-specific IgG antibody responses induced by monovalent NoV VLPs or multivalent VLP mix immunization. Termination sera of mice immunized with monovalent (MV) VLPs, GI.3 (Gr I), GII.4-1999 (Gr II), GII.17 (Gr III), or GII.4 SYD (Gr IV), or with the multivalent NoV VLP mix (MX, Gr V), or the carrier only (Control group, Ctrl) were analyzed with enzyme-linked immunosorbent assay (ELISA). (a) The mean optical density (OD490) at the serum dilution 1:200 of individual mice is illustrated with group mean and the standard error of the mean (SEM). The horizontal dashed line indicates maximum background level (cut-off limit). Mean IgG end-point titration curves specific for NoV (b) GI.3, (c) GII.4, (d) GII.17, and (e) GII.4 SYD VLPs with the SEM are shown.