Table 1.

Therapeutic strategies targeting glutamine metabolism in tumors.

Class	Drug	Status
Glutamine mimics	DON JHU–083 [164] Azaserine Acivicin	Limited by off target toxicity
Glutaminase (GLS) inhibitors	Compound 968 [166] CB-839 [167] BPTES [165,168]	Preclinical tool Successful in Phase I clinical trials [NCT02071927, NCT02071888] Preclinical tool
SLC1A5 inhibition	V-9302 [163] Benzylserine GPNA γ-FBP	Effective, preclinical tools
Glutamine depletion	L–Asparginase	Clinically used for hematological malignancies Limited by toxicity
Glutamate dehydrogenase (GLUD) inhibitors	EGCG R162	Preclinical tool compounds
Aminotransferase inhibitors	AOA	Used for tinnitus treatment Limited by toxicity
SLC7A11 or xCT inhibitors	Sulfasalazine Erastin	Pre-clinical tools Potent inducers of ferroptosis