Table 3.
Results of multivariate analysis (Cox’s proportional hazards model) of the effects of clinical and pathological characteristics and NOTCH3 mRNA expression on patients’ DSS.
| Patient Stratification | p Value | Hazard Ratio | 95.0% CI | |
|---|---|---|---|---|
| Gender (male) | 0.956 | 0.984 | 0.553 | 1.751 |
| NOTCH3 (above median) | 0.383 | 1.286 | 0.731 | 2.263 |
| Resection margin status (R1) | 0.126 | 0.614 | 0.328 | 1.147 |
| ASA score | ||||
| ASA III (reference value) | 0.725 | |||
| ASA I | 0.484 | 2.120 | 0.259 | 17.379 |
| ASA II | 0.773 | 0.915 | 0.501 | 1.671 |
| Primary tumor stage | ||||
| T4 (reference value) | 0.299 | |||
| T1 | 0.507 | 0.424 | 0.034 | 5.358 |
| T2 | 0.267 | 0.275 | 0.028 | 2.686 |
| T3 | 0.144 | 0.200 | 0.023 | 1.728 |
| Regional lymph nodes (N1) | 0.152 | 0.598 | 0.296 | 1.209 |
| Resection type (DP) | 0.661 | 1.163 | 0.593 | 2.283 |
ASA, American Society of Anesthesiologists score; CI, confidence interval; DP, distal pancreatectomy. Reference levels are displayed between brackets.