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. 2019 Oct 26;11(11):987. doi: 10.3390/v11110987

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cytokine and chemokine responses in mice that were infected with MA-EBOV. Groups of mice (n = 6) were infected intraperitoneally with 10 PFU of either EBOV/Mayinga-MA, EBOV/Makona-MA-PP1, EBOV/Makona-preMA, EBOV/Makona-rgMA, or the two single mutant viruses EBOV/Makona-rgMA-10979 or EBOV/Makona-rgMA-2357. Serum samples were collected on days 3 and 5 post-infection and expression levels of (A) IL1-β, (B) IL-6, (C) IL-22, (D), IFN-γ, (E) G-CSF/CSF-3, (F) Gro-α/KC, (G) IP-10, (H) MCP-1, (I) MCP-3, (J) IL-15/IL-15R, (K) MIP1-α, and (L) MIP-1β were determined by Luminex assay.