Figure 2.

Communication from adipose tissue to muscle cells leading to muscle atrophy and mobility disability. The green side represents the healthy adipose tissue, which presents adipogenic potential and balance through adipocyte stem cells (ASCs) regeneration and differentiation leading to metabolically flexible adipocytes and beneficial-secreted factors. The red side represents the unhealthy adipose tissue and impaired “adipogenic capacity”, which shows the effects of aging in ASCs that undergo to senescence. Senescence is characterized by irreversible arrest of cellular proliferation that establish a senescence-associated secretory phenotype (SASP), leading to maladaptive inflammation and cell death, which can ultimately mediate inter-organ pathology, including skeletal muscle pathology (mobility disability).