Table 2.
Intermittent HFD exposure and rat neurotransmitter receptors gene expression in the hypothalamus using the RT2 Profiler PCR Array. The bold underlined text highlights statistically significant changes compared to the chow controls.
| # | Unigene | Refseq | Symbol | Description | Fold Regulation | p Value |
|---|---|---|---|---|---|---|
| 1 | Rn.9991 | NM_017191 | Adra1a | Adrenergic, alpha-1A-, receptor | −1.0 | 0.877 |
| 2 | Rn.11314 | NM_024483 | Adra1d | Adrenergic, alpha-1D-, receptor | −1.8 | 0.236 |
| 3 | Rn.170171 | NM_012739 | Adra2a | Adrenergic, alpha-2A-, receptor | −1.0 | 0.887 |
| 4 | Rn.10206 | NM_012492 | Adrb2 | Adrenergic, beta-2-, receptor, surface | −1.1 | 0.649 |
| 5 | Rn.32282 | NM_053019 | Avpr1a | Arginine vasopressin receptor 1A | 1.1 | 0.403 |
| 6 | Rn.10096 | NM_017205 | Avpr1b | Arginine vasopressin receptor 1B | −1.3 | 0.455 |
| 7 | Rn.86415 | NM_152845 | Brs3 | Bombesin-like receptor 3 | 1.4 | 0.230 |
| 8 | Rn.90997 | NM_013165 | Cckbr | Cholecystokinin B receptor | 1.5 | 0.341 |
| 9 | Rn.119395 | NM_080773 | Chrm1 | Cholinergic receptor, muscarinic 1 | 1.9 | 0.050 |
| 10 | Rn.10676 | NM_031547 | Chrm4 | Cholinergic receptor, muscarinic 4 | 1.7 | 0.005 |
| 11 | Rn.44293 | NM_017362 | Chrm5 | Cholinergic receptor, muscarinic 5 | 1.2 | 0.296 |
| 12 | Rn.10996 | NM_052805 | Chrna3 | Cholinergic receptor, nicotinic, alpha 3 | −1.1 | 0.548 |
| 13 | Rn.9697 | NM_024354 | Chrna4 | Cholinergic receptor, nicotinic, alpha 4 | −1.2 | 0.618 |
| 14 | Rn.40125 | NM_017078 | Chrna5 | Cholinergic receptor, nicotinic, alpha 5 | −1.6 | 0.588 |
| 15 | Rn.9696 | NM_057184 | Chrna6 | Cholinergic receptor, nicotinic, alpha 6 | −1.4 | 0.573 |
| 16 | Rn.9698 | NM_012832 | Chrna7 | Cholinergic receptor, nicotinic, alpha 7 | 1.3 | 0.283 |
| 17 | Rn.10301 | NM_017194 | Chrne | Cholinergic receptor, nicotinic, epsilon | 1.1 | 0.405 |
| 18 | Rn.89774 | NM_012784 | Cnr1 | Cannabinoid receptor 1 (brain) | 1.1 | 0.358 |
| 19 | Rn.24039 | NM_012546 | Drd1 | Dopamine receptor D1A | 1.6 | 0.066 |
| 20 | Rn.87299 | NM_012547 | Drd2 | Dopamine receptor D2 | −1.1 | 0.672 |
| 21 | Rn.138110 | NM_012768 | Drd5 | Dopamine receptor D5 | 1.1 | 0.413 |
| 22 | Rn.30059 | NM_031028 | Gabbr1 | Gamma-aminobutyric acid (GABA) B receptor 1 | 1.1 | 0.498 |
| 23 | Rn.162814 | NM_031802 | Gabbr2 | Gamma-aminobutyric acid (GABA) B receptor 2 | −1.1 | 0.525 |
| 24 | Rn.28463 | NM_183326 | Gabra1 | Gamma-aminobutyric acid (GABA) A receptor, alpha 1 | −1.1 | 0.443 |
| 25 | Rn.48180 | NM_001135779 | Gabra2 | Gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 | 1.3 | 0.020 |
| 26 | Rn.81205 | NM_080587 | Gabra4 | Gamma-aminobutyric acid (GABA) A receptor, alpha 4 | 1.1 | 0.759 |
| 27 | Rn.10368 | NM_017295 | Gabra5 | Gamma-aminobutyric acid (GABA) A receptor, alpha 5 | 1.2 | 0.254 |
| 28 | Rn.29890 | NM_021841 | Gabra6 | Gamma-aminobutyric acid (GABA) A receptor, alpha 6 | −2.2 | 0.359 |
| 29 | Rn.207157 | NM_012956 | Gabrb1 | Gamma-aminobutyric acid (GABA) A receptor, beta 1 | 1.3 | 0.010 |
| 30 | Rn.233948 | NM_017065 | Gabrb3 | Gamma-aminobutyric acid (GABA) A receptor, beta 3 | 1.3 | 0.045 |
| 31 | Rn.10927 | NM_017289 | Gabrd | Gamma-aminobutyric acid (GABA) A receptor, delta | −1.3 | 0.676 |
| 32 | Rn.54455 | NM_023091 | Gabre | Gamma-aminobutyric acid (GABA) A receptor, epsilon | 1.3 | 0.357 |
| 33 | Rn.10366 | NM_080586 | Gabrg1 | Gamma-aminobutyric acid (GABA) A receptor, gamma 1 | 1.1 | 0.140 |
| 34 | Rn.230132 | NM_183327 | Gabrg2 | Gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 1.2 | 0.040 |
| 35 | Rn.10369 | NM_024370 | Gabrg3 | Gamma-aminobutyric acid (GABA) A receptor, gamma 3 | 1.1 | 0.554 |
| 36 | Rn.81067 | NM_031733 | Gabrq | Gamma-aminobutyric acid (GABA) receptor, theta | 1.4 | 0.098 |
| 37 | Rn.33552 | NM_017291 | Gabrr1 | Gamma-aminobutyric acid (GABA) receptor, rho 1 | −1.1 | 0.617 |
| 38 | Rn.48659 | NM_017292 | Gabrr2 | Gamma-aminobutyric acid (GABA) receptor, rho 2 | −1.2 | 0.325 |
| 39 | Rn.11225 | NM_172092 | Gcgr | Glucagon receptor | −1.1 | 0.666 |
| 40 | Rn.29971 | NM_031608 | Gria1 | Glutamate receptor, ionotropic, AMPA 1 | 1.2 | 0.106 |
| 41 | Rn.91361 | NM_017261 | Gria2 | Glutamate receptor, ionotropic, AMPA 2 | 1.1 | 0.015 |
| 42 | Rn.74049 | NM_032990 | Gria3 | Glutamate receptor, ionotrophic, AMPA 3 | −1.1 | 0.721 |
| 43 | Rn.10449 | NM_017241 | Grik1 | Glutamate receptor, ionotropic, kainate 1 | 1.0 | 0.702 |
| 44 | Rn.87696 | NM_019309 | Grik2 | Glutamate receptor, ionotropic, kainate 2 | 1.1 | 0.082 |
| 45 | Rn.10049 | NM_012572 | Grik4 | Glutamate receptor, ionotropic, kainate 4 | −1.0 | 0.670 |
| 46 | Rn.74042 | NM_031508 | Grik5 | Glutamate receptor, ionotropic, kainate 5 | 1.2 | 0.059 |
| 47 | Rn.9840 | NM_017010 | Grin1 | Glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 1.1 | 0.254 |
| 48 | Rn.9710 | NM_012573 | Grin2a | Glutamate receptor, ionotropic, N-methyl D-aspartate 2A | −1.0 | 0.888 |
| 49 | Rn.9711 | NM_012574 | Grin2b | Glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 1.1 | 0.342 |
| 50 | Rn.9709 | NM_012575 | Grin2c | Glutamate receptor, ionotropic, N-methyl D-aspartate 2C | 1.0 | 0.971 |
| 51 | Rn.87787 | NM_017011 | Grm1 | Glutamate receptor, metabotropic 1 | 1.1 | 0.073 |
| 52 | Rn.41715 | NM_001105712 | Grm3 | Glutamate receptor, metabotropic 3 | −1.5 | 0.147 |
| 53 | Rn.89046 | NM_022666 | Grm4 | Glutamate receptor, metabotropic 4 | −1.1 | 0.724 |
| 54 | Rn.29972 | NM_017012 | Grm5 | Glutamate receptor, metabotropic 5 | 1.1 | 0.356 |
| 55 | Rn.44615 | NM_022920 | Grm6 | Glutamate receptor, metabotropic 6 | −1.1 | 0.753 |
| 56 | Rn.10409 | NM_031040 | Grm7 | Glutamate receptor, metabotropic 7 | 1.2 | 0.055 |
| 57 | Rn.44420 | NM_022202 | Grm8 | Glutamate receptor, metabotropic 8 | −1.1 | 0.312 |
| 58 | Rn.10316 | NM_012706 | Grpr | Gastrin releasing peptide receptor | 1.6 | 0.136 |
| 59 | Rn.9893 | NM_013074 | Hcrtr2 | Hypocretin (orexin) receptor 2 | 1.3 | 0.159 |
| 60 | Rn.81032 | NM_017018 | Hrh1 | Histamine receptor H 1 | 1.3 | 0.272 |
| 61 | Rn.162272 | NM_131909 | Hrh4 | Histamine receptor H4 | −1.7 | 0.428 |
| 62 | Rn.44486 | NM_012585 | Htr1a | 5-hydroxytryptamine (serotonin) receptor 1A | −1.1 | 0.723 |
| 63 | Rn.138109 | NM_022225 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | 1.0 | 0.796 |
| 64 | Rn.34834 | NM_012852 | Htr1d | 5-Hydroxytryptamine (serotonin) receptor 1D | 1.0 | 0.893 |
| 65 | Rn.44301 | NM_021857 | Htr1f | 5-hydroxytryptamine (serotonin) receptor 1F | −1.1 | 0.630 |
| 66 | Rn.10294 | NM_017254 | Htr2a | 5-hydroxytryptamine (serotonin) receptor 2A | 1.2 | 0.682 |
| 67 | Rn.9935 | NM_012765 | Htr2c | 5-hydroxytryptamine (serotonin) receptor 2C | −1.0 | 0.949 |
| 68 | Rn.55109 | NM_024394 | Htr3a | 5-hydroxytryptamine (serotonin) receptor 3a | −1.2 | 0.444 |
| 69 | Rn.10094 | NM_012853 | Htr4 | 5-hydroxytryptamine (serotonin) receptor 4 | 1.1 | 0.051 |
| 70 | Rn.87132 | NM_022938 | Htr7 | 5-hydroxytryptamine (serotonin) receptor 7 | 1.0 | 0.409 |
| 71 | Rn.64505 | NM_023968 | Npy2r | Neuropeptide Y receptor Y2 | 1.7 | 0.108 |
| 72 | Rn.10532 | NM_012869 | Npy5r | Neuropeptide Y receptor Y5 | 1.1 | 0.691 |
| 73 | Rn.127792 | NM_022695 | Ntsr2 | Neurotensin receptor 2 | 1.0 | 0.849 |
| 74 | Rn.6841 | NM_012871 | Oxtr | Oxytocin receptor | 1.4 | 0.118 |
| 75 | Rn.82760 | NM_138978 | Prokr2 | Prokineticin receptor 2 | 1.4 | 0.234 |
| 76 | Rn.32256 | NM_031115 | Sctr | Secretin receptor | −1.2 | 0.630 |
| 77 | Rn.42915 | NM_012719 | Sstr1 | Somatostatin receptor 1 | 1.2 | 0.258 |
| 78 | Rn.9929 | NM_019348 | Sstr2 | Somatostatin receptor 2 | 1.0 | 0.762 |
| 79 | Rn.9936 | NM_013036 | Sstr4 | Somatostatin receptor 4 | 1.1 | 0.417 |
| 80 | Rn.89609 | NM_012667 | Tacr1 | Tachykinin receptor 1 | 1.1 | 0.215 |
| 81 | Rn.202846 | NM_080768 | Tacr2 | Tachykinin receptor 2 | −1.8 | 0.333 |
| 82 | Rn.9702 | NM_017053 | Tacr3 | Tachykinin receptor 3 | 1.2 | 0.286 |
| 83 | Rn.1820 | NM_012515 | Tspo | Translocator protein | 1.1 | 0.489 |