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. 2019 Nov 1;11(11):1012. doi: 10.3390/v11111012

Figure 10.

Figure 10

Genetic signature identified under the HIV-1 envelope GP41 cytoplasmic tail (CT or CD) between NF-κB activation (NA) and Kennedy Epitope (KE) domains associate to clade B HIV-1 chronic compared to recent viruses. The X axis represents amino acids (AA) composing the GP41 CT NA and KE sequence (direction N to C). The Y axis represents the normalized AA frequency identified at each position of the GP41 CT, NA and KE sequence for each category of infection. The top line box represents chronic virus envelope GP41 CT NA and KE sequences represented individuals (N = 105) and the bottom for RC viruses within 136 MDRI and TF (N = 126). As indicated for Weblogo analysis, the overall height of each stack indicates the sequence conservation at that position (measured in bits), whereas the height of symbols within the stack reflects the relative frequency of the corresponding amino or nucleic acid at that position. The valine (V) signature was localized at position 876 of alignment and position 751 referring to HXB2 numbering (D751V) and identified by a red asterisk.