Figure 4:

Ablation of the OFC→NAcc circuit disrupts action-value updating following unrewarded outcomes. (A-B) Regression coefficients from the logistic regression model examining the likelihood of persisting with the same choice based on whether the same choice in the last four trials was rewarded (left) or unrewarded (right) in rats where the OFC→NAcc pathway was targeted before (solid line) and after (dashed line) administration of saline (A) or DT. (C-D) Reinforcement learning parameters for the reversal phase in rats where the OFC→NAcc pathway was targeted before (open bars) and after (closed bars) administration of saline (C) or DT (D). Values plotted are thin lines representing individual rats and averages ± SEM.# p<0.07, * p<0.05 denotes that values after DT/saline administration were different from those before DT/saline administration. Related to Supplemental Figure 6.