. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Biomed Pharmacother. 2019 May 15;115:108897. doi: 10.1016/j.biopha.2019.108897

Table 1.

Effect of t-TUCB on diabetes-induced alteration in level of testosterone, weight of penile and testes.

Parameters	Groups
	Normal Control	Diabetic Control (DC)	DC + t-TUCB 0.1 mg/kg	DC + t-TUCB 0.3 mg/kg
Serum testosterone (ng/dL)	96 ± 3^a	44 ± 4	56 ± 3	71 ± 3^***
Penile weight (g)	0.24 ± 0.01^a	0.18 ± 0.01	0.19 ± 0.01^*	0.24 ± 0.01^***
Testis weight (g)	0.59 ± 0.02^a	0.13 ± 0.01	0.33 ± 0.02^***	0.51 ± 0.03^***

Level of testosterone and weights of penises and testes were reduced in the diabetic rats, in comparison to the normal healthy rats.

p < 0.001. The sEH inhibitor minimized a reduction in the levels of testosterone in diabetic rats. The t-TUCB also minimized a reduction in the weights of penises and testes of diabetic rats, in comparison to diabetic control rats.

p < 0.05.

^***

p < 0.001. Values are presented as mean ± SEM of 4 readings. One-way ANOVA followed by Dunnet’s test was used for statistical calculation. Diabetic control vs diabetic rats treated with sEH inhibitor.